Prof. Bräuchle's Research Group - Faculty for Chemistry and Pharmacy

Novel Drug Delivery Systems

Nanomedicine/Development of smart drug delivery systems: drug delivery with mesoporous silica nanoparticles, polyplexes and lipoplexes as synthetic viruses showing targeting, controlled release and depot effect. Live cell imaging of uptake and trafficking of these nanoparticles in order to visualize their behaviour  in living cells


Lächelt U., Kos P., Mickler F.M., Herrmann A., Salcher E.E., Rödl W., Badgujar N., Bräuchle C., Wagner E.
Fine-tuning of proton sponges by precise diaminoethanes and histidines in pDNA polyplexes
Nanomedicine 10 (2014), 35.

Argyo C., Weiß V., Bräuchle C., Bein T.
Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery
Chem. Mater. 26(1) (2014), 435.

Mackowiak S.A., Schmidt A., Weiss V., Argyo C., von Schirnding C., Bein T.*, Bräuchle C.*
Targeted Drug Delivery in Cancer Cells with Red Light Photoactivated Mesoporous Silica Nanoparticles
Nano Letters 13(6) (2013), 2576.

Torrano A.A., Blechinger J., Osseforth C., Argyo C., Reller A., Bein T., Michaelis J., Bräuchle C.
A fast analysis method to quantify nanoparticle uptake on a single cell level
Nanomedicine 8(11) (2013), 1815.

Blechinger J., Bauer A.T., de Andrade Torrano A., Gorzelanny C., Bräuchle C., Schneider S.W.
Uptake Kinetics and Nanotoxicity of Silica Nanoparticles are Cell Type Dependent
Small 9(23) (2013), 3970.
Inside cover picture for Small December 2013, 9(23)

Lebold T., Schloßbauer A., Schneider K., Schermelleh L., Leonhardt H., Bein T.*, Bräuchle C.*
Controlling the mobility of oligonucleotides in the nanochannels of mesoporous silica
Advanced Functional Materials 22(1) ,(2012), 106.
Cover picture for Advanced Functional Materials (January 2012, 22(1)

Mickler F.M., Möckl L., Ruthardt N., Ogris M., Wagner E., Bräuchle C.
Tuning nanoparticle uptake: Live-cell imaging reveals two distinct endocytosis mechanisms mediated by natural and artificial EGFR targeting ligand
Nano Lett. 12(7) ,(2012), 3417.

Ruthardt N., Lamb D.C., Bräuchle C.
Single-particle Tracking as a Quantitative Microscopy-based Approach to Unravel Cell Entry Mechanisms of Viruses and Pharmaceutical Nanoparticles
Molecular Therapy 19(7) (2011), 1199.

Mickler F.M., Vachutinsky Y., Oba M., Miyata K., Nishiyama N., Kataoka K., Bräuchle C., Ruthardt N.
Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging
Journal of Controlled Release 156 (2011), 364.

Ruthardt N., Bräuchle C.
Visualizing Uptake and Intracellular Trafficking of Gene Carriers by Single-Particle Tracking
in "Nucleic Acid Transfection"
Topics in Current Chemistry, Vol. 296/2010
Eds: Bielke W., Erbacher C.
Verlag Springer Berlin/Heidelberg (2010), S. 283-304

Sauer A.,Schloßbauer A., Ruthardt N., Cauda V., Bein T., Bräuchle C.
The Role of Endosomal Escape for Disulfide-Based Drug Delivery from Colloidal Mesoporous Silica Evaluated by Live-Cell Imaging
Nano Lett. 10,(2010), 3684.

Cauda V., Engelke H., Sauer A., Arcizet D., Bräuchle C., Rädler J., Bein T.
Colchicine-loaded lipid bilayer-coated 50 nm mesoporous nanoparticles efficiently induce microtubule depolymerization upon cell uptake
Nano Lett. 10(7), (2010), 2484.

Katayama Y., Burkacky O., Meyer M., Bräuchle C., Gratton E., Lamb D.C.
Real-time Nanomicroscopy via Three-Dimensional Single-Particle Tracking
ChemPhysChem 10(14) (2009), 2458.

Lebold T., Jung C., Michaelis J., Bräuchle C.*
Nanostructured Silica Materials As Drug-Delivery Systems for Doxorubicin: Single Molecule and Cellular Studies
Nanoletters 9(8) (2009), 2877.

Sauer A.M., de Bruin K.G., Ruthardt N., Mykhaylyk O., Plank C., Bräuchle C.
Dynamics of magnetic lipoplexes studied by single particle tracking in living cells
Journal of Controlled Release 137 (2009), 136.
On this publication in “Journal of Controlled Release” the following cover story was published:
Journal of Controlled Release 137 (2009), 89.

de Bruin K., Fella C., Ogris M., Wagner E., Ruthardt* N., Bräuchle C.
Dynamics of photoinduced endosomal release of polyplexes
J. Contr. Release 130 (2008), 175.

Lange S., Katayama Y., Schmid M., Burkacky O., Bräuchle C., Lamb D.C., Jansen R.-P.
Simultaneous Transport of Different Localized mRNA Species Revealed by Live-Cell Imaging
Traffic 9, (2008), 1256.

de Bruin K. Ruthardt N., von Gersdorff K., Bausinger R., Wagner E., Ogris M., Bräuchle C.*
Cellular dynamics of EGF receptor targeted synthetic viruses
Mol. Therapy 15(7), (2007), 1297

Bausinger R., von Gersdorff K., Braeckmans K., Ogris M., Wagner E., Bräuchle* C., Zumbusch A.
The Transport of Nanosized Gene Carriers Unravelled by Live Cell Imaging
Angew. Chem. 118(10) (2006) 1598.
Angew. Chem. internat. Edition 45(10) (2006) 1568. 




Universität München
Department Chemie
Physikalische Chemie I
Butenandtstr. 11
D-81377 München
Phone: +49-89-2180-77547
Mail: Prof. C. Braeuchle
more information...


v. Schirnding C., Giopanou I., Hermawan A., Wehl L., Ntaliarda G., Illes B., Datz S., Geisslinger F., Bartel K., Sommer A.-K., Lianou M., Weiß V., Feckl J., Vollmar A.M., Bräuchle C., Stathopoulos G.T., Wagner E., Roidl A., Bein T., Engelke H.
Synergistic Combination of Calcium and Citrate in Mesoporous Nanoparticles Targets Pleural Tumors
Chem 7(2)(2021)480-494Link

Möckl L., Lamb D.C., Bräuchle C. 

Super-resolved Fluorescence Microscopy: Nobel Prize in Chemistry 2014 for Eric Betzig, Stefan Hell, and William E. Moerner
Angew. Chem. Int. Ed. 53(51) (2014), 13972.  Link

Jung C., Schwaderer P., Dethlefsen M., Köhn R., Michaelis J., Bräuchle C. 
Visualization of the Self Assembly of Silica Nanochannels reveals growth mechanism 
Nature Nanotechnology, 6 (2011), 87. Link

Seisenberger G., Ried M.U., Endreß T., Büning H., Hallek M., Bräuchle C.
Real-Time Single Molecule Imaging of the Infection Pathway of an Adeno-associated Virus 
Science, 294(2001) 1929. Link