Prof. Bräuchle's Research Group - Faculty for Chemistry and Pharmacy

Publications 2010 - 2019


Despras G., Möckl L., Heitmann A., Stamer I., Bräuchle C., Lindhorst T.K.*
A photoswitchable trivalent cluster mannoside to probe the effect of ligand orientation in bacterial adhesion
ChemBioChem 20 (2019), 2373. Link


Beil A., Steudel F.A., Bräuchle C., Grützmacher H., Möckl L.*
Bisacylphosphane oxides as photo-latent cytostatic agents and potential photo-latent anticancer drugs
Scientific Reports 9:6003 (2019) Link


Broda E., Torrano A.A., Möckl L., Löbbert L., Bräuchle C., Engelke H.
Invasiveness of cells changes their interaction behaviour with the glycocalyx
Advanced Biosystems 2 (2018), 1800083 Link


Raddaoui N.*, Stazzoni S.*, Möckl L., Viverge B., Geiger F., Engelke H., Bräuchle C., Carell T.*
Dendrimer-Based Signal Amplification of Click-Labelled DNA in Situ
ChemBioChem 18, (2017), 1716. Link


Höppner S., Kinting S., Torrano A., Schindlbeck U., Bräuchle C., Zarbock R., Wittman T., Griese M.
Quantification of volume and lipid filling of intracellular vesicles carrying the ABCA3 transporter
BBA - Molecular Cell Research, 1864(12) (2017), 2330. Link


Bräuchle C.
Spektromikroskopie für biologische Fragestellungen in der Physikalischen Chemie, p. 85
Beitrag im Buch “Unendliche Weiten: Kreuz und quer durchs Chemie-Universum”
Eds.: T.K. Lindhorst, H-J.Quadbeck-Seeger, Gesellschaft Deutscher Chemiker Wiley VCH Verlag GmbH (2017)


Vater M., Möckl L., Gormanns V., Schultz Fademrecht C., Mallmann A.M., Ziegart-Sadowska K., Zaba M., Frevert M.L., Bräuchle C., Holsboer F., Rein T., Schmidt U., Kirmeier T.*
New insights into the intracellular distribution pattern of cationic amphiphilic drugs
Scientific Reports 7 (2017), Article number 44277. Link


Kolbe K., Möckl L., Sohst V., Brandenburg J., Engel R., Malm S., Bräuchle C., Holst O., Lindhorst T.K.*, Reiling N.*
Azido pentoses: A New Tool to Efficiently Label Mycobacterium tuberculosis Clinical Isolates
ChemBioChem 18 (2017), 1172. Link

Cover picture for ChemBioChem 13/2017


Uhl B., Hirn S., Immler R., Mildner K., Möckl L., Sperandio M., Bräuchle C., Reichel C., Zeuschner D., Krombach F.
The Endothelial Glycocalyx Controls Interactions of Quantum Dots with the Endothelium and Their Translocation across the Blood−Tissue Border
ACS Nano, 11(2), (2017), 1498. Link


Möckl L., Hirn S., Torrano A.A., Uhl B., Bräuchle C., Krombach F.
The Glycocalyx Regulates the Uptake of Nanoparticles by Human Endothelial Cells In Vitro
Nanomedicine, 12(3), (2017), 207. Link

352.   Sommer A.-K., Hermawan A., Mickler F.M., Ljepoja B., Knyazev P., Bräuchle C., Ullrich A., Wagner E., Roidl A.
Salinomycin co-treatment enhances tamoxifen cytotoxicity in luminal A breast tumor cells by facilitating lysosomal degradation of receptor tyrosine kinases
Oncotarget 7(31) (2016), 50461. Link
351.   Möckl L., Fessele C., Despras G., Bräuchle C., Lindhorst T.K.
En route from artificial to natural: Evaluation of inhibitors of mannose-specific adhesion of E. coli under flow
Biochimica et Biophysica Acta 1860 (2016), 2031. Link
350.   Torrano A.A., Herrmann R., Strobel C., Rennhak M., Engelke H. Reller A., Hilger I., Wixforth A., Bräuchle C.*
Cell Membrane Penetration and Mitochondrial Targeting by Platinum-Decorated Ceria Nanoparticles
Nanoscale (2016), 13352. Link
349.   Weiss V., Argyo C., Torrano A.A., Strobel C., Mackowiak S.A., Schmidt A., Datz S., Gatzenmeier T., Hilger I., Bräuchle C.*, Bein T.*
Dendronized Mesoporous Silica Nanoparticles Provide an Internal Endosomal Escape Mechanism for Successful Cytosolic Drug Release
Microporous and Mesoporous Materials 227 (2016), 242.  Link
348.   Datz S., Argyo C., Gattner M.J., Weiss V., Brunner K., Bretzler J., von Schirnding C., Torrano A.A., Spada F., Vrabel M., Engelke H., Bräuchle C., Carell T., Bein T.
Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release
Nanoscale (2016), 8101.  Link
347.   Möller K., Müller K., Engelke H., Bräuchle C., Wagner E.*, Bein T. *
Highly Efficient siRNA Delivery from Core-Shell Mesoporous Silica Nanoparticles with Multifunctional Polymer Caps
Nanoscale (2016), 4007. Link

Möckl L., Lindhorst T.K.., Bräuchle C.*
Artificial Formation and Tuning of Glycoprotein Networks on Live Cell Membranes: A Single-Molecule Tracking Study
ChemPhysChem 17(6) (2016), 829.  Link

Inside cover picture for ChemPhysChem March 2016, 17(6)


345.   Möckl L., Müller A., Bräuchle C., Lindhorst T.K.*
Switching first contact: photocontrol of E. coli adhesion to human cells
Chem. Comm. 52 (2016), 1254.  Link
344.   Weiss V., Argyo C., de Andrade Torrano A., Strobel C., Mackowiak S.A., Gatzenmeier T., Hilger I., Bräuchle C., Bein T.
Dendronized Mesoporous Silica Nanoparticles Provide an Internal Endosomal Escape Mechanism for Successful Cytosolic Drug Release
arXiv:1510.05930 [] (2015) Link
343.   Datz S., Argyo C., Gattner M., Weiss V., Brunner K., Bretzler J., von Schirnding C., Spada F., Engelke H., Vrabel M., Bräuchle C., Carell T., Bein T.*
Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release
arXiv:1510.03649 [] (2015) Link
342.   Möller K., Müller K., Engelke H., Bräuchle C., Wagner E., Bein T.
Highly Efficient siRNA Delivery from Core-Shell Mesoporous Silica Nanoparticles with Multifunctional Polymer Caps
arXiv:1509.03107 [q-bio.SC] (2015) Link
341.   Möckl L., Horst A., Kolbe K., Lindhorst T*., Bräuchle C.*
Microdomain Formation Controls Spatiotemporal Dynamics of Cell Surface Glycoproteins
ChemBioChem 16(14) (2015), 2023. Link

Inside cover picture for ChemBioChem September 2015, 14(16)


Broda E., Mickler F., Lächelt U., Morys S., Wagner E., Bräuchle C.
Assessing potential peptide targeting ligands by quantification of cellular adhesion of model nanoparticles under flow conditions
J Controlled Release 213 (2015), 79  Link

CeNS Publication Award 2015 (Category: Best interdisciplinary publication)

339.   Bräuchle C., Weiß V.
Entwicklung von Nanofähren zur gezielten Krebsbekämpfung mit Hilfe superhochauflösender Lichtmikroskopie
GDCh Aktuelle Wochenschau zum "Internationalen Jahr des Lichts", Woche 16, (2015) Link
338.   Niedermayer S., Weiss V., Herrmann A., Schmidt A., Datz S., Müller K., Wagner E., Bein T.*, Bräuchle C.*
Multifunctional Polymer-Capped Mesoporous Silica Nanoparticles for pH-Responsive Targeted Drug Delivery
Nanoscale (2015), 7953  Link
337.   Kos P., Lächelt U., Herrmann A., Mickler F.M., Döblinger M., He D., Krhač Levačić A., Morys S., Bräuchle C., Wagner E. 
Histidine-rich stabilized polyplexes for cMet-directed tumor-targeted gene transfer
Nanoscale (2015), 5350 Link
336.   Prescher J., Baumgärtel V., Ivanchenko S., Torrano A.A., Bräuchle C., Müller B., Lamb D.C.  
Super-Resolution Imaging of ESCRT-proteins at HIV-1 Assembly Sites
PLoS Pathogens (2015), DOI:10.1371/journal.ppat.1004677 Link

Pavlichenko I., Broda E., Fukuda Y., Szendrei K., Hatz A.K., Scarpa G., Lugli P., Bräuchle C., Lotsch B.V.  
Bringing One-Dimensional Photonic Crystals to a New Light: An Electrophotonic Platform for Chemical Mass Transport Visualisation and Cell Monitoring
Mater. Horiz. 2 (2015), 299. Link

Front cover picture for Mater. Horiz. 01 May 2015, Issue 3

334.   Brunner K., Harder J., Halbach T., Willibald J., Spada F., Gnerlich F., Sparrer K., Beil A., Möckl L., Bräuchle C., Conzelmann K.-K., Carell T.* 
Cell-Penetrating and Neurotargeting Dendritic siRNA Nanostructures
Angew. Chem. Int. Ed. 53(51) (2015), 1946.  Link

Dendritische Nanostrukturen zur rezeptorvermittelten Aufnahme von siRNA in neurale Zellen
Angew. Chem. 126(51) (2015), 1968.  Link
333.   Strobl F.G., Breyer D., Link P., Torrano A.A., Bräuchle C., Schneider M.F., Wixforth A. 
A surface acoustic wave-driven micropump for particle uptake investigation under physiological flow conditions in very small volumes
Beilstein Journal of Nanotechnology 6 (2015), 414.  Link
332.   Strobl F.G., Seitz F., Westerhausen C., Reller A., Torrano A.A., Bräuchle C., Wixforth A., Schneider, M.F. 
Intake of silica nanoparticles by giant lipid vesicles: influence of particle size and thermodynamic membrane state
Beilstein Journal of Nanotechnology 5 (2014), 2468. Link
331.   Invited Article 

Möckl L., Lamb D.C., Bräuchle C. 
Super-resolved Fluorescence Microscopy: Nobel Prize in Chemistry 2014 for Eric Betzig, Stefan Hell, and William E. Moerner
Angew. Chem. Int. Ed. 53(51) (2014), 13972.  Link

Superhochauflösende Mikroskopie: Nobelpreis in Chemie 2014 für Eric Betzig, Stefan Hell und William E. Moerner
Angew. Chem. 126(51) (2014), 14192.  Link

330.   Davies M., Rühle B., Li C., Müllen K., Bein T.*, Bräuchle C.*  
Insights into Nanoscale Electrophoresis of Single Dye Molecules in Highly Oriented Mesoporous Silica Channels
The Journal of Physical Chemistry C 118(41) (2014), 24013. Link
329.   Torrano A.A., Bräuchle C.  
Precise quantification of silica and ceria nanoparticle uptake revealed by 3D fluorescence microscopy
Beilstein Journal of Nanotechnology (2014), 1616. Link
328.   Argyo C., Weiss V., Bräuchle C., Bein T.  
Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery
Chem. Mater. 26(1) (2014), 435. Link
327.   Lächelt U., Kos P., Mickler F.M., Herrmann A., Salcher E.E., Rödl W., Badgujar N., Bräuchle C., Wagner E.  
Fine-tuning of proton sponges by precise diaminoethanes and histidines in pDNA polyplexes
Nanomedicine 10 (2014), 35.  Link
326.   Strobel C., Torrano A.A., Herrmann R., Malissek M., Bräuchle C., Reller A., Treuel L., Hilger I.  
Effects of the physicochemical properties of titanium dioxide nanoparticles, commonly used as sun protection agents, on microvascular endothelial cells
J. Nanopart. Res. 16:2130 (2014), 1.  Link
325.   Torrano A.A., Blechinger J., Bräuchle C.  
Trafficking and Intracellular Distribution of Nanoparticles (Subchapter 6.4 of Chapter 6 "Biological Responses to Nanomaterials") 
In "Safety Aspects of Engineered Nanomaterials" 
Eds.: Luther W., Zweck A.
Pan Stanford Publishing (2013), p. 157
324.   Rühle B., Davies M., Bein T., Bräuchle C.  
Fluorescence Microscopy Studies of Porous Silica Materials
Z. Naturforsch. 68b (2013), 423. Link
323.   Mackowiak S.A., Schmidt A., Weiss V., Argyo C., von Schirnding C., Bein T.*, Bräuchle C.*  
Targeted Drug Delivery in Cancer Cells with Red Light Photoactivated Mesoporous Silica Nanoparticles
Nano Letters 13(6) (2013), 2576. Link

see also LMU Press Release in English and German as well as NIM News
322.   Blechinger J., Bauer A.T., Torrano A.A., Gorzelanny C., Bräuchle C., Schneider S.W.  
Uptake Kinetics and Nanotoxicity of Silica Nanoparticles are Cell Type Dependent
Small 9(23)(2013), 3970. Link

Inside cover picture for Small December 2013, 9(23)

321.   Mackowiak S., Bräuchle C.  
Study of Single Molecule Dynamics in Mesoporous Systems, Glasses and Living Cells 
In "Nonequilibrium Statistical Physics of Small Systems: Fluctuation relations and beyond" 
Eds.: Klages R., Just W., Jarzynski C.
Wiley VCH Weinheim (2013), p. 393.
320.  Torrano A.A., Blechinger J., Osseforth C., Argyo C., Reller A., Bein T., Michaelis J., Bräuchle C.
A fast analysis method to quantify nanoparticle uptake on a single cell level
Nanomedicine 8(11)  (2013), 1815. Link
319.  Albertazzi L., Mickler F., Pavan G.M., Salomone F., Bardi G., Panniello M., Amir E., Kang T., Killops K., Bräuchle C., Amir R., Hawker C.
Enhanced bioactivity of internally functionalized cationic dendrimers with PEG cores
Biomacromolecules 13 (2012), 4089. Link
318.  Sax G., Feil F., Schulze S., Jung C., Bräuchle C., Winter G.
Release pathways of interferon α2a molecules from lipid twin screw extrudates revealed by single molecule fluorescence microscopy
Journal of Controlled Release 162 (2012), 295. Link
317.  Mickler F.M., Möckl L., Ruthardt N., Ogris M., Wagner E., Bräuchle C.
Tuning nanoparticle uptake: Live-cell imaging reveals two distinct endocytosis mechanisms mediated by natural and artificial EGFR targeting ligand
Nano Lett. 12(7) (2012), 3417. Link
316.  Davies M., Wochnik A., Feil F., Jung C., Bräuchle C., Scheu C., Michaelis J.
Synchronous Emission from Nanometric Silver Particles through Plasmonic Coupling on Silver Nanowires
ACS Nano, 6(7) (2012), 6049. Link
315.  Lebold T., Michaelis J., Bein T., Bräuchle C.*
Single Molecule Spectroscopy 
in "Characterization of Solid Materials and Heterogeneous Catalysts: From Structure to Surface Reactivity", Vol. 1/2012 
Eds: Che M., Védrine Jacques C.
Wiley-VCH Verlag (2012), S. 585-607 
314.  Schloßbauer A., Sauer A.M., Cauda V., Schmidt A., Engelke H., Rothbauer U., Zolghadr K., Leonhardt H., Bräuchle C.*, Bein T.*
Cascaded Photoinduced Drug Delivery to Cells from Multifunctional Core-Shell Mesoporous Silica 
Advanced Healthcare Materials 1(3) (2012), 316. Link
313.  Rühle B., Davies M., Lebold T., Bräuchle C.*, Bein T.*
Highly Oriented Mesoporous Silica Channels Synthesized in Microgrooves and Visualized with Single Molecule Diffusion 
ACS Nano 6(3) (2012), 1948. Link
312.  Feil F., Cauda V., Bein T.,*, Bräuchle C.*
Direct Visualization of Dye and Oligonucleotide Diffusion in Silica Filaments with Collinear Mesopores 
Nano Lett. 12(3) (2012), 1354. Link

Feil F., Naumov S., Michaelis J., Valiullin R., Enke D., Kärger J., 
Bräuchle C.

Single-Particle and Ensemble Diffusivities—Test of Ergodicity
Angewandte Chemie 124(5) (2012), 1178. Link
Angewandte Chemie Internat. Edition 51(5) (2012), 1152. Link

see also News NIM

Cover picture for Angewandte Chemie Internat. Edition (January 2012, 51(5)


Lebold T., Schloßbauer A., Schneider K., Schermelleh L., Leonhardt H., Bein T.*, Bräuchle C.*
Controlling the mobility of oligonucleotides in the nanochannels of mesoporous silica
Advanced Functional Materials, 22(1) (2012), 106. Link
Cover picture for Advanced Functional Materials (January 2012, 22(1)


309. Mickler F.M., Vachutinsky Y., Oba M., Miyata K., Nishiyama N., Kataoka K., Bräuchle C., Ruthardt N.
Effect of integrin targeting and PEG shielding on polyplex micelle internalization studied by live-cell imaging
Journal of Controlled Release 156 (2011), 364. Link
308. Ruthardt N., Lamb D.C., Bräuchle C.
Single-particle Tracking as a Quantitative Microscopy-based Approach to Unravel Cell Entry Mechanisms of Viruses and Pharmaceutical Nanoparticles
Molecular Therapy 19(7) (2011), 1199. Link
307. Baumgärtel V., Ivanchenko S., Dupont A., Sergeev M., Wiseman P.W., Kräusslich H.-G., Bräuchle C., Müller B., Lamb D.C.
Live-cell visualization of dynamics of HIV budding site interactions with an ESCRT component
Nature Cell Biology 13 (2011), 469. Link
306. Lebold T., Michaelis J., Bräuchle C.* 
The complexity of mesoporous silica nanomaterials unraveled by single molecule microscopy 
Phys. Chem. Chem. Phys. 13 (2011), 5017. Link

Jung C., Schwaderer P., Dethlefsen M., Köhn R., Michaelis J., Bräuchle C. 
Visualization of the Self Assembly of Silica Nanochannels reveals growth mechanism 
Nature Nanotechnology 6 (2011), 87. Link

Figure from this publication: cover picture for Nature Nanotechnology, Issue 2 (February 2011 Volume 6 No 2) 

304.  Davies M., Jung C., Wallis P., Schnitzler T., Li C.,  Müllen K., Bräuchle C. *
Photophysics of New Photostable Rylene Derivatives: Applications in Single-Molecule Studies and Membrane Labelling 
ChemPhysChem 12 (2011), 1588. Link
303.  Michaelis J., Bräuchle C.
 Reporters in the Nanoworld – Diffusion of single molecules in mesoporous materials 
Chem. Soc. Rev. 39 (2010), 4731. Link 
302.  Blechinger J., Herrmann R., Kiener D., Garcia-Garcia F., Scheu C., Reller A., Bräuchle C. 
Perylene-labeled Silica Nanoparticles: Synthesis and Characterization of Three Novel Silica Nanoparticle Species for Live Cell Imaging 
Small 6(21), (2010), 2427. Link 
301. Sauer A., Schloßbauer A., Ruthardt N., Cauda V., Bein T., Bräuchle C.
The Role of Endosomal Escape for Disulfide-Based Drug Delivery from Colloidal Mesoporous Silica Evaluated by Live-Cell Imaging 
Nano Letters, 10 (2010), 3684. Link

300.  Ruthardt N., Bräuchle C. 
Visualizing Uptake and Intracellular Trafficking of Gene Carriers by Single-Particle Tracking 
in "Nucleic Acid Transfection" 
Topics in Current Chemistry, Vol. 296/2010 
Eds: Bielke W., Erbacher C. 
Verlag Springer Berlin/Heidelberg (2010), S. 283-304 Link 

299.  Cauda V., Engelke H., Sauer A., Arcizet D., Bräuchle C., Rädler J., Bein T. 
Colchicine-loaded lipid bilayer-coated 50 nm mesoporous nanoparticles efficiently induce microtubule depolymerization upon cell uptake 
Nano Letters, 10(7) (2010), 2484. Link 

298.  Wirth S., Wallek A.U., Zernickel A., Feil F., Sztiller-Sikorska M., Lesiak-Mieczkowska K., Bräuchle C., Lorenz I.-P., Czyz M. 
Tautomerization of 2-nitroso-N-arylanilines by coordination as N,N'-chelate ligands to rhenium(I) complexes and the anticancer activity of newly synthesized oximine rhenium(I) complexes against human melanoma and leukemia cells in vitro 
Journal of Inorganic Biochemistry 104(7) (2010), 774. Link 

297.  Bräuchle C. 
Exploring Nanostructured Systems with Single Molecule Probes: From Nanoporous Materials to Living Cells 
in "Single Molecule Spectroscopy in Chemistry, Physics and Biology" Nobel Symposium 
Springer Series in Chemical Physics, Vol. 96, Part 10 
Eds: Gräslund A., Rigler R., Widengren J. 
Verlag: Springer Berlin Heidelberg (2010), S. 537



Universität München
Department Chemie
Physikalische Chemie I
Butenandtstr. 11
D-81377 München
Phone: +49-89-2180-77547
Mail: Prof. C. Braeuchle
more information...


v. Schirnding C., Giopanou I., Hermawan A., Wehl L., Ntaliarda G., Illes B., Datz S., Geisslinger F., Bartel K., Sommer A.-K., Lianou M., Weiß V., Feckl J., Vollmar A.M., Bräuchle C., Stathopoulos G.T., Wagner E., Roidl A., Bein T., Engelke H.
Synergistic Combination of Calcium and Citrate in Mesoporous Nanoparticles Targets Pleural Tumors
Chem 7(2)(2021)480-494Link

Möckl L., Lamb D.C., Bräuchle C. 

Super-resolved Fluorescence Microscopy: Nobel Prize in Chemistry 2014 for Eric Betzig, Stefan Hell, and William E. Moerner
Angew. Chem. Int. Ed. 53(51) (2014), 13972.  Link

Jung C., Schwaderer P., Dethlefsen M., Köhn R., Michaelis J., Bräuchle C. 
Visualization of the Self Assembly of Silica Nanochannels reveals growth mechanism 
Nature Nanotechnology, 6 (2011), 87. Link

Seisenberger G., Ried M.U., Endreß T., Büning H., Hallek M., Bräuchle C.
Real-Time Single Molecule Imaging of the Infection Pathway of an Adeno-associated Virus 
Science, 294(2001) 1929. Link