LMU Header LMU M;uuml;nchen Fakultät Chemie und Pharmazie
Faculty Home page  |  IT Services / Webmail  |  Intranet

Prof. Bräuchle's Research Group

Welcome to Prof. Bräuchle's Research Group
Department of Chemistry, University of Munich


Curriculum Vitae

Address: Department Chemie and Center for NanoScience (CeNS)
Ludwig-Maximilians-Universität München
Butenandtstr. 11, Haus E
D-81377 Munich, Germany
Contact Mail: Christoph.Braeuchle@cup.lmu.de
Phone: +49-89-2180-77549
Fax: +49-89-2180-77550
Web: www.cup.lmu.de/pc/braeuchle


1968 - 1973: Studies of chemistry and physics at TU Berlin and University Tübingen
1978: Ph. D. in physical chemistry, LMU München
1982: Habilitation in physical chemistry at LMU München

Professional Experience

1979-1980: Postdoc Fellowship IBM San José (California) USA
1981-1983: Teaching und Research Assistant LMU München
1984-1986: C2-Assistant Professor LMU München


1986: C4- Professorship (Chair) Physical Chemistry TU Berlin
1988: C4-Professorship (Chair) Physical Chemistry, LMU München
1994: C4-Professorship (Chair) Physical Chemistry, Director NMI/Univ. Tübingen
Since 1988: C4 Professor (Chair) for Physical Chemistry, LMU München
Since 2012: The official C4 Professorship for Physical Chemistry at the LMU has been prolonged until March 2016 so far

Activities in the Scientific Community

1995-1997: Dean of the Faculty of Chemistry and Pharmacy, LMU München
1998-2000: Member of the senate, LMU München
1994-1997: Head of the GDCh-Photochemistry board
1996-2001: Member of the Review Board of the VW-Stiftung (Intra- and Intermolecular Electron Transfer)
1997-2002: Initiation of the funding program of the VW-Stiftung on "Physics,Chemistry and Biology with Single Molecules"
1997-2002: Member of the Minerva German-Israeli Foundation
2000-2008: Member of the Board of the Center for NanoScience (CeNS) at LMU München
2002-2004: Speaker of the Research Project "ForNano"
2004-2005: Chairman of the Department of Chemistry, LMU München
2004-2012: Speaker: International Elite Graduate School "Nano-Bio-Technology"
2008-2012: Member of the DFG Review Board for Science (Physical Chemistry)
2006-2011: Member of the Board of the Excellence Cluster "Nanosystems Initiative Munich" (NIM) at the LMU München
2012-2017: Member of the Board of the Excellence Cluster "Nanosystems Initiative Munich" (NIM) at the LMU München
2006-2011: Coordinator of the Research Area A "Protein Biophysics and Imaging" of the Excellence Cluster "Center for Integrated Protein Science" (CIPS) at the LMU München
2012-2017: Coordinator of the Research Area A "Protein Biophysics and Imaging" of the Excellence Cluster "Center for Integrated Protein Science" (CIPS) at the LMU München
2000-2014: Member of the Editorial Board of ChemPhysChem
since 2006: Deutsches Museum Munich: Member of the Board of Trustees
since 2018: NIM Senior Member
------- Member of numerous advisory committees in Germany and foreign scientific institutions

Research Interests

Spectroscopy, Imaging and Manipulation of Single Molecules and Nanoparticles in Bio- and Nano-Sciences:

  1. Dynamics of single molecules in nanoporous systems: mechanistical studies of translation, rotation, adsorption and spectral diffusion of single molecules in mesoporous silica structures and other nanoporous systems
  2. Development of smart drug delivery systems/nanomedicine: drug delivery with mesoporous silica nanoparticles, polyplexes and lipoplexes/targeting, controlled release and depot effect, live cell imaging of uptake and trafficking in living cells
  3. Live cell imaging and single virus tracing: observation of the infection pathway of a single virus into a living cell and production (self-assembly and budding) of viruses in infected cells for HIV and Herpes
  4. Nanoparticles and human health: live cell imaging of uptake and trafficking of nanoparticles (SiO2, TiO2, ZnO, CeO, Pt etc.) in endothelial cells in an artificial blood circulation model and toxicity measurements
  5. Hybrid nanosystems for light collection: combination of light harvesting complexes (photosynthesis) with metal nanoparticles (plasmons) as advanced biomimetic systems for solar energy collection
  6. Force spectroscopy with single polymer chains, especially polysiloxanes


More than 350 peer-reviewed papers published in scientific journals including high-ranking journals like "Nature", "Science", "Nature Materials", "Nature Nanotechnology", "Nature Cell Biology", "Phys. Rev. Lett." etc. For Details see link Publications.


2015: Walther-Nernst-Denkmünze (awarded by the Deutsche Bunsengesellschaft at the Bunsentagung 2015)

14.05.2015: Überreichung der Walther-Nernst-Denkmünze durch den Ersten Vorsitzenden der Deutschen Bunsengesellschaft, Prof. J. Sauer, und Laudatio gehalten von Prof. K. Meerholz/Universität Köln

2014: Guest professorship at the University of California San Francisco
2012: Guest professorship at the University of California San Diego
2011: Guest professorship at the University of California Santa Barbara
2009: Elected Member of the Academia Europaea since May 2009
2008: Participant and invited presentation at the Nobel Symposium II "Single Molecules in Chemistry, Physics and Biology", Stockholm/Sweden
2002: Karl Heinz Beckurts Preis 2002
2002: Member of the Bavarian Academy of Sciences
2001: Award at the Munich Business Plan Competition for the contribution "Single Virus Tracing"
1998: Participant and invited presentation at the Nobel Symposium "Single Molecules in Chemistry, Physics and Biology", Stockholm/Sweden
1994: Guest professorship at the University Paris
1993: Guest professorship at the University of California, Los Angeles
1993: Philip Morris Research Award "New Ways in Material Science"

Member of special funding programs

DFG SFB 455: "Viral Functions and Immune Modulation" (finished 2004)
DFG SFB 486: "Manipulation of Matter on the Nanometer Scale" (1999-2009)
DFG SFB 533: "Light Induced Dynamics of Biopolymers" (1999-2007)
DFG SFB 646: "Network in Genome Expression and Maintenance" (2005-2007)
DFG SFB 749: "Dynamik und Intermediate molekularer Transformationen" (2007-2011)
DFG SPP 1175: "Application of ultrasensitive fluorescence methods to the envelopment and budding of viruses with a focus on HIV" (2005-2009)
DFG SPP 1313: "Bioactivity and cellular uptake of distinct nanoparticles in human endothelial cells" (2008-2013)
LMU München NIM: Excellence Cluster "Nanosystems Initiative Munich" (2006-2012), (2012-2017), NIM Senior Member (since 2018)
LMU München CiPSM: Exzellenzcluster "Center for Integrated Protein Science Munich" (2006-2012), (2012-2017)

"ForNano" Bayerische Forschungsstiftung (2002-2004)
DFG – Normalverfahren
Elitenetzwerk Bayern

DFG SFB = DFG Sonderforschungsbereich
DFG SPP = DFG Schwerpunktprogramm

weitere Informationen hier

Basché Bunsenmagazin

ChemPhysChem Board Member Profile

Universität München
Department Chemie
Physikalische Chemie I
Butenandtstr. 11
D-81377 München
Phone: +49-89-2180-77547
Mail: Prof. C. Braeuchle
more information...
Selected Papers

A photoswitchable trivalent cluster mannoside to probe the effect of ligand orientation in bacterial adhesion, ChemBioChem 20 (2019), 2373. more information... 

Bisacylphosphane oxides as photo-latent cytostatic agents and potential photo-latent anticancer drugs, Scientific Reports 9:6003 (2019). more information... 

Invasiveness of cells changes their interaction behaviour with the glycocalyx, Advanced Biosystems 2, (2018),1800083. more information... 

Dendrimer-Based Signal Amplification of Click-Labelled DNA in Situ, ChemBioChem 18, (2017), 1716. more information... 

Quantification of volume and lipid filling of intracellular vesicles carrying the ABCA3 transporter, BBA - Molecular Cell Research, 1864(12) (2017), 2330. more information... 

Spektromikroskopie für biologische Fragestellungen in der Physikalischen Chemie, p. 85, Beitrag im Buch “Unendliche Weiten: Kreuz und quer durchs Chemie-Universum”, Eds.: T.K. Lindhorst, H-J.Quadbeck-Seeger, Gesellschaft Deutscher Chemiker Wiley VCH Verlag GmbH (2017). more information... 

New insights into the intracellular distribution pattern of cationic amphiphilic drugs, Scientific Reports (2017), Article number 44277. more information... 

Azido pentoses: A New Tool to Efficiently Label Mycobacterium tuberculosis Clinical Isolates, ChemBioChem 18 (2017), 1172. more information... 

The Endothelial Glycocalyx Controls Interactions of Quantum Dots with the Endothelium and Their Translocation across the Blood−Tissue Border ACS Nano, 11(2), (2017), 1498. more information... 

The Glycocalyx Regulates the Uptake of Nanoparticles by Human Endothelial Cells In Vitro, Nanomedicine 12(3) (2017), 207.  more information... 

Salinomycin co-treatment enhances tamoxifen cytotoxicity in luminal A breast tumor cells by facilitating lysosomal degradation of receptor tyrosine kinases, Oncotarget 7(31) (2016), 50461. more information... 

En route from artificial to natural: Evaluation of inhibitors of mannose-specific adhesion of E. coli under flow , Biochimica et Biophysica Acta 1860 (2016), 2031. more information... 

Cell Membrane Penetration and Mitochondrial Targeting by Platinum-Decorated Ceria Nanoparticles, Nanoscale 8 (2016), 13352. more information... 

Dendronized Mesoporous Silica Nanoparticles Provide an Internal Endosomal Escape Mechanism for Successful Cytosolic Drug Release, Microporous and Mesoporous Materials 227 (2016), 242. more information... 

Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release, Nanoscale (2016), 8101. more information... 

Highly efficient siRNA delivery from core–shell mesoporous silica nanoparticles with multifunctional polymer caps, Nanoscale 8 (2016), 4007. more information... 

Artificial Formation and Tuning of Glycoprotein Networks on Live Cell Membranes: A Single-Molecule Tracking Study, ChemPhysChem 17(6) (2016), 829. more information... 

Switching first contact: photocontrol of E. coli adhesion to human cells, Chem. Comm. 52 (2016), 1254. more information...